Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.43 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.31 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.31 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20554328 | 1.00 | ACHE (0.43) | ACHEDRD2DRD3HTR2AHTR2C | |
| SCHEMBL20554690 | 0.78 | ADRA2A (0.31) | ACHEADRA2A | |
| SCHEMBL31316665 | 0.77 | ADRA2A (0.50) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL1265344 | 0.77 | ADRA2A (0.50) | DRD2DRD3HTR2CHTR2BADRA2A | |
| SCHEMBL1265342 | 0.77 | ADRA2A (0.50) | DRD2DRD3HTR2CHTR2BADRA2A | |
| SCHEMBL23976381 | 0.77 | ADRA2A (0.50) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL31316850 | 0.77 | ADRA2A (0.50) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL14275635 | 0.77 | ADRA2A (0.50) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL1266132 | 0.77 | ADRA2A (0.50) | DRD2DRD3HTR2CHTR2BADRA2A | |
| SCHEMBL3847929 | 0.77 | ADRA2A (0.50) | HTR2AHTR2CHTR2BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332455-B2 | α,β-unsaturated amide compound | KYOWA KIRIN CO., LTD. (JP) | 2022-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332455-B2 | α,β-unsaturated amide compound | NR1H2, NCOA1, NR0B1 | ACHE 3830/4885ADRA2A 95/4885ADRA2B 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.