Stephanine

Stephanine

SCHEMBL29543045

COc1cccc2c1C[C@@H]1c3c(cc4c(c3-2)OCO4)CCN1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 5/20 1.00
HTR2A P28223 2/20 0.79
HTR2C P28335 2/20 0.79
HTR2B P41595 2/20 0.79
POLB P06746 2/20 0.74
CASP6 P55212 2/20 0.74
KMT2A Q03164 2/20 0.74
KDM4E B2RXH2 2/20 0.74
LMNA P02545 2/20 0.74
TDP2 O95551 1/20 0.74
MAPT P10636 1/20 0.74
RAD52 P43351 1/20 0.74
ADRA1A P35348 3/20 0.72
ADRA1D P25100 2/20 0.72
ADRA1B P35368 2/20 0.72
MEN1 O00255 1/20 0.72
APAF1 O14727 1/20 0.72
GAA P10253 1/20 0.72
RAB9A P51151 1/20 0.72
CASP7 P55210 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Stephanine SCHEMBL27780270 1.00 DRD2 (1.00) DRD2HTR2AHTR2CHTR2BPOLB
Stephanine SCHEMBL25472587 1.00 DRD2 (1.00) DRD2HTR2AHTR2CHTR2BPOLB
Crebanine SCHEMBL30690403 0.88 HTR2A (1.00) DRD2HTR2AHTR2CHTR2BPOLB
Crebanine SCHEMBL25472585 0.88 HTR2A (1.00) DRD2HTR2AHTR2CHTR2BPOLB
SCHEMBL11249690 0.87 DRD2 (0.76) DRD2HTR2AHTR2CHTR2BPOLB
Dicentrine SCHEMBL31237199 0.85 KDM4E (1.00) DRD2HTR2AHTR2CHTR2BPOLB
Dicentrine SCHEMBL679684 0.85 KDM4E (1.00) DRD2HTR2AHTR2CHTR2BPOLB
Dicentrine SCHEMBL6369440 0.85 KDM4E (1.00) DRD2HTR2AHTR2CHTR2BPOLB
Dicentrine SCHEMBL30475130 0.85 KDM4E (1.00) DRD2HTR2AHTR2CHTR2BPOLB
Dicentrine SCHEMBL31237335 0.85 KDM4E (1.00) DRD2HTR2AHTR2CHTR2BPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119654404-A Methods and compositions for producing oligodendrocyte progenitor cells 特雷尔赫德生物系统股份有限公司 2025-03-18 CN claimed
CN-119285647-A Cepharanthine crystal and preparation method thereof 南京工业大学 2025-01-10 CN claimed
CN-115541794-B Quality control method for radix Stephaniae Cepharanthae medicinal material, decoction pieces, standard decoction lyophilized powder and formula granule 北京康仁堂药业有限公司 2024-12-13 CN claimed
CN-116253742-B Cepharanthine crystal and preparation method thereof 南京工业大学 2024-10-11 CN claimed
CN-116253742-A Cepharanthine crystal and preparation method thereof 南京工业大学 2023-06-13 CN claimed
CN-116036130-A Antibacterial composite material combining Chinese and western medicine and preparation method and application thereof 长沙绿湘环保科技有限公司 2023-05-02 CN claimed
CN-122094937-A Cannabinoid compounds and uses thereof 2026-05-26 CN disclosed
CN-119770568-A Traditional Chinese medicine composition, pharmaceutical preparation and application 云南中医药大学 2025-04-08 CN disclosed
CN-115996752-B Compositions and methods for treating epilepsy J·大卫格莱斯顿研究所-根据J·大卫格莱斯顿遗嘱的遗嘱信托 2025-04-01 CN disclosed
CN-119285647-A Cepharanthine crystal and preparation method thereof 南京工业大学 2025-01-10 CN disclosed
CN-119215075-A Methods for treating and inhibiting the progression of seizures 阿勒根公司 2024-12-31 CN disclosed
CN-117582510-B Use of metal-polyphenol complexes in nucleic acid delivery systems 湖南长星生物医药有限公司 2024-11-22 CN disclosed
CN-118903472-A Modified ligand-gated ion channels and methods of use 霍华休斯医学研究院 2024-11-08 CN disclosed
CN-110872218-B Method for synthesizing benzofluorenone compound under catalysis of Cu 浙江工业大学 2022-10-04 CN disclosed
CN-114908061-A Pangolin coronavirus xCoV and application thereof 北京化工大学 2022-08-16 CN disclosed
CN-114908062-A Application of mefloquine hydrochloride or mefloquine hydrochloride in preparation of drugs for treating coronavirus infectious diseases 北京化工大学 2022-08-16 CN disclosed
CN-113069433-B Euphorbia lathyris element nanometer preparation and preparation method and application thereof 北京中医药大学 2022-08-02 CN disclosed
CN-114657149-A Application of ceratin in preparing medicine for treating coronavirus infectious diseases 北京化工大学 2022-06-24 CN disclosed
CN-113046327-B Pangolin coronavirus xCoV and application thereof and application of medicine in resisting coronavirus infection 北京化工大学 2022-05-10 CN disclosed
CN-114450030-A Targeting OTUB1 in immunotherapy 得克萨斯州大学系统董事会 2022-05-06 CN disclosed