Crebanine

Crebanine

SCHEMBL30690403

COc1ccc2c(c1OC)CC1c3c(cc4c(c3-2)OCO4)CCN1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 1.00
HTR2C P28335 2/20 1.00
HTR2B P41595 2/20 1.00
DRD2 P14416 4/20 0.79
SOST Q9BQB4 2/20 0.77
KDM4E B2RXH2 2/20 0.71
LMNA P02545 2/20 0.71
POLB P06746 2/20 0.71
CASP6 P55212 2/20 0.71
KMT2A Q03164 2/20 0.71
TDP2 O95551 1/20 0.71
MAPT P10636 1/20 0.71
RAD52 P43351 1/20 0.71
BCHE P06276 2/20 0.68
ACHE P22303 2/20 0.68
ADRA1A P35348 3/20 0.63
ADRA1D P25100 2/20 0.63
ADRA1B P35368 2/20 0.63
TDP1 Q9NUW8 2/20 0.63
MEN1 O00255 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Crebanine SCHEMBL25472585 1.00 HTR2A (1.00) HTR2AHTR2CHTR2BDRD2SOST
Hydrochloric Acid SCHEMBL18304151 0.89 HTR2A (0.79) HTR2AHTR2CHTR2BDRD2SOST
Stephanine SCHEMBL29543045 0.88 DRD2 (1.00) HTR2AHTR2CHTR2BDRD2SOST
Stephanine SCHEMBL25472587 0.88 DRD2 (1.00) HTR2AHTR2CHTR2BDRD2SOST
Stephanine SCHEMBL27780270 0.88 DRD2 (1.00) HTR2AHTR2CHTR2BDRD2SOST
SCHEMBL32690236 0.87 SOST (1.00) HTR2AHTR2CHTR2BDRD2SOST
SCHEMBL15444612 0.87 SOST (1.00) HTR2AHTR2CHTR2BDRD2SOST
Dicentrine SCHEMBL679684 0.83 KDM4E (1.00) HTR2AHTR2CHTR2BDRD2SOST
Dicentrine SCHEMBL31237199 0.83 KDM4E (1.00) HTR2AHTR2CHTR2BDRD2SOST
Dicentrine SCHEMBL6369440 0.83 KDM4E (1.00) HTR2AHTR2CHTR2BDRD2SOST

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4579240-A1 CF48 KIDNEY INJURY BIOMARKER AND USE THEREOF IN KIDNEY INJURY TREATMENT DRUG Guangzhou Kangrun Biotechnology Co., Ltd. (CN) 2025-07-02 EP disclosed
CN-115343479-B Cf48 kidney injury biomarker and application thereof in kidney injury treatment medicines 广州市康润生物科技有限公司 2024-10-22 CN disclosed
WO-2023231803-A1 CF48 KIDNEY INJURY BIOMARKER AND USE THEREOF IN KIDNEY INJURY TREATMENT DRUG 广州市康润生物科技有限公司 2023-12-07 WO disclosed