Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427784 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL7276972 | 0.84 | ALDH1A1 (0.58) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL4324495 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL4968519 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL2192561 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL21958010 | 0.83 | ALDH1A1 (0.62) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL11247916 | 0.83 | TSHR (0.62) | ALDH1A1LMNAKDM4EHSD17B10TSHR | |
| SCHEMBL4672146 | 0.83 | ALDH1A1 (0.57) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL6965125 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNAKDM4EHSD17B10POLB | |
| SCHEMBL5487519 | 0.80 | KMT2A (0.47) | ALDH1A1LMNAKDM4EHSD17B10CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119365467-A | Aza-tetraepoxy aza compounds and uses thereof | 基因泰克公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-114466846-B | Substituted tricyclic compounds as PRMT5 inhibitors and application thereof | 南京圣和药业股份有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-112334465-B | Tricyclic substituted oxaspiro derivatives, preparation and pharmaceutical use thereof | 上海海雁医药科技有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-113527101-B | Novel compound, polymer, process for producing the same, photosensitive resin composition, pattern forming process, cured film, and electronic component | 信越化学工业株式会社 | 2024-04-23 | — | — | CN | disclosed |
| CN-112645946-B | Substituted tricyclic compounds as PRMT5 inhibitors and application thereof | 南京圣和药业股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-112125886-B | Tricyclic compounds as PRMT5 inhibitors and application thereof | 南京圣和药物研发有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-113087700-B | Spirocyclic tetrahydroquinazolines | 苏州亚盛药业有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-115197212-A | Substituted tricyclic compound, preparation method and application thereof | 南京圣和药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-115197214-A | Preparation method of substituted tricyclic PRMT5 inhibitor | 南京圣和药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-115192576-A | Composition containing substituted tricyclic PRMT5 inhibitor and application thereof | 南京圣和药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-114466846-A | Substituted tricyclic compound as PRMT5 inhibitor and application thereof | 南京圣和药业股份有限公司 | 2022-05-10 | — | — | CN | disclosed |