Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4137654 | 0.84 | ALDH1A1 (0.47) | KMT2AALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL2422410 | 0.82 | FOLH1 (0.53) | KMT2AALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7121210 | 0.82 | LMNA (0.41) | KMT2AALDH1A1HPGDGALR3RAB9A | |
| SCHEMBL19014341 | 0.81 | TSHR (0.44) | KMT2AALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL20682204 | 0.81 | TSHR (0.44) | KMT2AALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL2863807 | 0.81 | BCAT2 (0.46) | KMT2AALDH1A1HPGDRAB9AKDM4E | |
| SCHEMBL31722804 | 0.81 | ALDH1A1 (0.44) | KMT2AALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL8965146 | 0.81 | ALDH1A1 (0.44) | KMT2AALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL11388477 | 0.81 | ALDH1A1 (0.44) | KMT2AALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL2427784 | 0.80 | ALDH1A1 (0.57) | KMT2AALDH1A1LMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189836-B2 | Therapeutic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2019-01-29 | — | — | US | disclosed |
| US-20110039314-A1 | Composition for Catalytic Amide Production and Uses Thereof | LOYOLA UNIVERSITY OF CHICAGO (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110039314-A1 | Composition for Catalytic Amide Production and Uses Thereof | LOYOLA UNIVERSITY OF CHICAGO (US) | 2011-02-17 | — | — | US | disclosed |
| WO-2011020025-A1 | COMPOSITION FOR CATALYTIC AMIDE PRODUCTION AND USES THEREOF | LOYOLA UNIVERSITY OF CHICAGO (US) | 2011-02-17 | — | — | WO | disclosed |
| CN-1310967-C | Catalyst component for olefin polymerization reaction and its catalyst | CHINA PETROCHEMICAL CORP (CN) | 2007-04-18 | — | — | CN | disclosed |
| EP-1499306-A4 | BICYCLIC AMIDES | MERCK & CO INC (US) | 2007-03-28 | — | — | EP | disclosed |
| CN-1715301-A | Catalyst component for olefin polymerization reaction and its catalyst | CHINA PETROCHEMICAL CORP (CN) | 2006-01-04 | — | — | CN | disclosed |
| EP-1499306-A2 | BICYCLIC AMIDES | Merck & Co., Inc. (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086288-A2 | BICYCLIC AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189836-B2 | Therapeutic compounds, compositions and methods of use thereof | JAK2, JAK1, JAK3 | KMT2A 2377/4885ALDH1A1 1702/4885HPGD 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.