Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.56 |
| ▸ | JAK2 | O60674 | 5/20 | 0.56 |
| ▸ | JAK1 | P23458 | 4/20 | 0.56 |
| ▸ | JAK3 | P52333 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359224 | 1.00 | TYK2 (0.56) | TYK2JAK2JAK1JAK3L3MBTL1 | |
| SCHEMBL29551761 | 0.92 | TYK2 (0.57) | TYK2JAK2JAK1JAK3L3MBTL1 | |
| SCHEMBL28359206 | 0.91 | JAK2 (0.68) | TYK2JAK2JAK1JAK3L3MBTL1 | |
| SCHEMBL29551775 | 0.89 | TYK2 (0.55) | TYK2JAK2JAK1JAK3P2RX7 | |
| SCHEMBL28359048 | 0.89 | TYK2 (0.55) | TYK2JAK2JAK1JAK3P2RX7 | |
| SCHEMBL29922678 | 0.83 | L3MBTL1 (0.42) | L3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL28362527 | 0.83 | L3MBTL1 (0.42) | L3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL29922746 | 0.82 | TYK2 (0.81) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL28359040 | 0.82 | TYK2 (0.81) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29922630 | 0.80 | TYK2 (0.54) | TYK2JAK2JAK1JAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |