Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922584 | 1.00 | SYK (0.35) | SYKPTGS2TYK2KCNH2HRH3 | |
| SCHEMBL29552335 | 0.90 | PTGS2 (0.37) | SYKPTGS2TYK2KCNH2HRH3 | |
| SCHEMBL28362527 | 0.87 | L3MBTL1 (0.42) | SYKPTGS2PDE7AATMKMT2A | |
| SCHEMBL29922678 | 0.87 | L3MBTL1 (0.42) | SYKPTGS2PDE7AATMKMT2A | |
| SCHEMBL29551775 | 0.84 | TYK2 (0.55) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28359048 | 0.84 | TYK2 (0.55) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29922581 | 0.77 | JAK2 (0.52) | TYK2POLBJAK2JAK1JAK3 | |
| SCHEMBL28359240 | 0.77 | JAK2 (0.52) | TYK2POLBJAK2JAK1JAK3 | |
| SCHEMBL29552160 | 0.77 | L3MBTL1 (0.46) | SYKPTGS2TYK2PDE7AJAK2 | |
| SCHEMBL15091096 | 0.73 | SYK (0.56) | SYKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |