Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089867 | 1.00 | MAOA (0.50) | MAOAOPRL1RPS6KA3MAPTBACE1 | |
| SCHEMBL13014935 | 0.87 | CHRNB2 (0.41) | MAOAOPRL1MAPTCHRNB2CHRNA4 | |
| SCHEMBL30084892 | 0.87 | CHRNB2 (0.41) | MAOAOPRL1MAPTCHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL287323 | 0.85 | CHRNB2 (0.40) | MAOAOPRL1MAPTCHRNB2CHRNA4 | |
| SCHEMBL26131159 | 0.83 | OPRL1 (0.41) | MAOAOPRL1MAPTBACE1KDM4E | |
| SCHEMBL21988069 | 0.83 | ALOX5AP (0.40) | OPRL1BACE1CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL240676 | 0.81 | NUDT1 (0.42) | OPRL1MAPTBACE1KDM4ECHRNB2 | |
| Hydrochloric Acid SCHEMBL239926 | 0.80 | KDM4E (0.43) | OPRL1MAPTBACE1KDM4ECHRNB2 | |
| SCHEMBL24753039 | 0.79 | MAOA (0.35) | MAOAOPRL1MAPTGAAKDM4E | |
| SCHEMBL30120243 | 0.79 | MAOA (0.35) | MAOAOPRL1MAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |