Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922678 | 0.90 | L3MBTL1 (0.42) | L3MBTL1SLC6A2SLC6A4SYKPDE7A | |
| SCHEMBL28362527 | 0.90 | L3MBTL1 (0.42) | L3MBTL1SLC6A2SLC6A4SYKPDE7A | |
| SCHEMBL29552335 | 0.85 | PTGS2 (0.37) | SYKPDE7APTGS2JAK2JAK1 | |
| SCHEMBL29552239 | 0.83 | L3MBTL1 (0.47) | L3MBTL1SLC6A2SLC6A4SYKPDE7A | |
| SCHEMBL29551761 | 0.82 | TYK2 (0.57) | L3MBTL1SLC6A2SLC6A4JAK2JAK1 | |
| SCHEMBL29922584 | 0.77 | SYK (0.35) | SYKPDE7APTGS2JAK2JAK1 | |
| SCHEMBL28359081 | 0.77 | SYK (0.35) | SYKPDE7APTGS2JAK2JAK1 | |
| SCHEMBL29552398 | 0.76 | JAK2 (0.54) | MAPKAPK2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL29552431 | 0.74 | SYK (0.48) | SYK | |
| SCHEMBL29552492 | 0.70 | SYK (0.46) | SYKMAPKAPK2PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |