Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29564197 | 0.81 | ADORA2A (0.42) | ADORA2AMBOAT4 | |
| SCHEMBL29631138 | 0.80 | DCPS (0.44) | LMNATLR7HRH4 | |
| SCHEMBL20952805 | 0.78 | HRH3 (0.36) | LMNASLC5A2 | |
| SCHEMBL29563950 | 0.74 | LATS1 (0.33) | — | |
| SCHEMBL19520171 | 0.70 | PRMT5 (0.56) | PRMT5LMNATLR8TLR7HRH4 | |
| SCHEMBL29671993 | 0.70 | PRMT5 (0.56) | PRMT5LMNATLR8TLR7HRH4 | |
| SCHEMBL3617192 | 0.66 | DHFR (0.54) | PRMT5LMNATLR8TLR7HRH4 | |
| SCHEMBL29517215 | 0.66 | DHFR (0.54) | PRMT5LMNATLR8TLR7HRH4 | |
| SCHEMBL13051982 | 0.65 | APLNR (0.39) | LMNATLR7SLC5A2 | |
| SCHEMBL16466554 | 0.64 | PRMT5 (0.47) | PRMT5LMNATLR8TLR7HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976609-A1 | PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-04-06 | — | — | EP | claimed |
| EP-3976609-A1 | PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-04-06 | — | — | EP | disclosed |