Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29374548 | 0.89 | TSHR (0.47) | TSHRHTR2CALDH1A1GLAFKBP1A | |
| SCHEMBL7996223 | 0.88 | TSHR (0.57) | TSHRHTR2CALDH1A1GLAFKBP1A | |
| SCHEMBL7994521 | 0.88 | TSHR (0.57) | TSHRHTR2CALDH1A1GLAFKBP1A | |
| SCHEMBL1576471 | 0.88 | TSHR (0.57) | TSHRHTR2CALDH1A1GLAFKBP1A | |
| SCHEMBL29504123 | 0.82 | HTR2C (0.53) | TSHRHTR2CALDH1A1GLAFKBP1A | |
| SCHEMBL29407160 | 0.82 | HTR2C (0.53) | TSHRHTR2CALDH1A1GLAFKBP1A | |
| SCHEMBL29661399 | 0.81 | HTR2C (0.49) | TSHRHTR2CALDH1A1GLAFKBP1A | |
| SCHEMBL23491956 | 0.80 | MASP2 (0.53) | TSHRHTR2CHTR2B | |
| SCHEMBL8304207 | 0.80 | NPC1 (0.43) | TSHRHTR2CHTR2BSMN1; SMN2NPC1 | |
| SCHEMBL8304205 | 0.80 | NPC1 (0.43) | TSHRHTR2CHTR2BSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12576040-B2 | Ionizable lipids and methods of manufacture and use thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2026-03-17 | — | — | US | disclosed |
| US-20250367131-A1 | IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF | George Mason Research Foundation, Inc. | 2025-12-04 | — | — | US | disclosed |
| CN-116917266-A | Ionizable lipids and methods of making and using the same | 乔治梅森研究基金会公司 | 2023-10-20 | — | — | CN | disclosed |
| EP-4228658-A1 | IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF | George Mason Research Foundation, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| US-20220218622-A1 | IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2022-07-14 | — | — | US | disclosed |
| WO-2022081750-A1 | IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF | George Mason Research Foundation, Inc. (US) | 2022-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12576040-B2 | Ionizable lipids and methods of manufacture and use thereof | NPC1L1, NSUN3, CETP | TSHR 1672/4885HTR2C 3666/4885ALDH1A1 1813/4885 |
| US-20250367131-A1 | IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF | NPC1L1, PLA2G4A, PLA2G2A | TSHR 2739/4885HTR2C 4867/4885ALDH1A1 2988/4885 |
| US-20220218622-A1 | IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF | NPC1L1, PLA2G4A, PLA2G2A | TSHR 2672/4885HTR2C 4871/4885ALDH1A1 3237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.