Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 12/20 | 0.34 |
| ▸ | GUSB | P08236 | 3/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26808265 | 1.00 | HTR3E (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29567043 | 0.94 | HTR6 (0.37) | HTR6GUSBSRC | |
| SCHEMBL26837336 | 0.94 | HTR6 (0.37) | HTR6GUSBSRC | |
| SCHEMBL24310583 | 0.90 | RIPK2 (0.38) | HTR6GUSBACVR1 | |
| SCHEMBL26858387 | 0.90 | GUSB (0.42) | HTR6GUSB | |
| SCHEMBL26806483 | 0.90 | ALOX12 (0.39) | KCNH2 | |
| SCHEMBL26809994 | 0.88 | GUSB (0.36) | HTR6GUSBACVR1 | |
| SCHEMBL24309786 | 0.86 | DGAT2 (0.40) | HTR6 | |
| SCHEMBL29567188 | 0.84 | HTR6 (0.37) | HTR6GUSBACVR1SRC | |
| SCHEMBL24310372 | 0.84 | HTR6 (0.37) | HTR6GUSBACVR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |