Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CCR4 | P51679 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309340 | 1.00 | USP1 (0.31) | USP1GAALMNAFABP4FABP5 | |
| SCHEMBL29566663 | 0.86 | SCN1A (0.32) | USP1GAALMNAFABP4FABP5 | |
| SCHEMBL24309702 | 0.86 | SCN1A (0.32) | USP1GAALMNAFABP4FABP5 | |
| SCHEMBL26808363 | 0.84 | ALDH1A1 (0.35) | USP1ALDH1A1MAPTTRPC5KDM4E | |
| SCHEMBL26808359 | 0.84 | GPR39 (0.35) | USP1GAALMNAFABP4FABP5 | |
| SCHEMBL29566434 | 0.81 | HTR1A (0.42) | USP1ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL24309279 | 0.81 | HTR1A (0.42) | USP1ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL29566636 | 0.81 | GAA (0.35) | GAALMNAALDH1A1MEN1KMT2A | |
| SCHEMBL26651236 | 0.81 | GAA (0.35) | GAALMNAALDH1A1MEN1KMT2A | |
| SCHEMBL24309792 | 0.80 | BRD4 (0.37) | GAALMNANPSR1KDM4ECCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |