Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.31 |
| ▸ | USP1 | O94782 | 5/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26808381 | 0.75 | HTR1A (0.41) | TRPC5USP1 | |
| SCHEMBL29566529 | 0.75 | HTR1A (0.41) | TRPC5USP1 | |
| SCHEMBL24309523 | 0.71 | POLB (0.36) | F2PRSS1PRSS2PRSS3NUDT1 | |
| SCHEMBL29566755 | 0.71 | POLB (0.36) | F2PRSS1PRSS2PRSS3NUDT1 | |
| SCHEMBL24309764 | 0.71 | USP1 (0.32) | NUDT1TRPC5USP1 | |
| SCHEMBL26808408 | 0.62 | HTR1A (0.45) | TRPC5USP1 | |
| SCHEMBL26808420 | 0.61 | HTR1A (0.44) | TRPC5USP1 | |
| SCHEMBL26808363 | 0.60 | ALDH1A1 (0.35) | TRPC5USP1 | |
| SCHEMBL8628190 | 0.58 | F10 (0.48) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL26806923 | 0.58 | MAPT (0.51) | NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |