Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | UGCG | Q16739 | 1/20 | 0.48 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739 | 0.93 | FFAR1 (0.46) | GBA1UGCGGBA2FFAR1AKR1B1 | |
| SCHEMBL2083 | 0.84 | SCN8A (0.46) | FFAR1AKR1B1ESR2SCN8AMEN1 | |
| SCHEMBL6961295 | 0.84 | FFAR1 (0.55) | GBA1UGCGGBA2FFAR1AKR1B1 | |
| SCHEMBL6960223 | 0.83 | GBA1 (0.54) | GBA1UGCGGBA2FFAR1AKR1B1 | |
| SCHEMBL2405 | 0.82 | DRD4 (0.50) | FFAR1AKR1B1ESR2BCHESCN8A | |
| SCHEMBL6960030 | 0.82 | ESR2 (0.59) | GBA1UGCGGBA2FFAR1AKR1B1 | |
| SCHEMBL6961121 | 0.81 | GBA1 (0.56) | GBA1UGCGGBA2FFAR1AKR1B1 | |
| SCHEMBL6952546 | 0.81 | FFAR1 (0.57) | GBA1UGCGGBA2FFAR1AKR1B1 | |
| SCHEMBL15341674 | 0.80 | MAOA (0.62) | BCHESCN8ATSHRMEN1KMT2A | |
| SCHEMBL2401 | 0.80 | ESR2 (0.50) | FFAR1AKR1B1ESR2TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |