Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | GPR39 | O43194 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.53 |
| ▸ | FABP1 | P07148 | 1/20 | 0.51 |
| ▸ | FABP6 | P51161 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29579974 | 0.88 | POLB (0.74) | POLBGAAKDM4EGPR39TSHR | |
| SCHEMBL18947190 | 0.85 | NPSR1 (0.66) | POLBGAAKDM4EGPR39HPGD | |
| SCHEMBL29579757 | 0.85 | GAA (0.57) | POLBGAAKDM4EGPR39HPGD | |
| SCHEMBL29579775 | 0.83 | ALDH1A1 (0.65) | POLBGAAKDM4EGPR39HPGD | |
| SCHEMBL14321086 | 0.81 | GAA (0.53) | POLBGAAKDM4EGPR39TSHR | |
| SCHEMBL14321655 | 0.81 | GAA (0.53) | POLBGAAKDM4EGPR39TSHR | |
| SCHEMBL27299487 | 0.81 | GAA (0.53) | POLBGAAKDM4EGPR39TSHR | |
| SCHEMBL29557927 | 0.77 | GPR39 (1.00) | GPR39SLC2A1 | |
| SCHEMBL29580040 | 0.77 | KDM4E (1.00) | POLBGAAKDM4EGPR39TSHR | |
| SCHEMBL14980562 | 0.77 | KDM4E (1.00) | POLBGAAKDM4EGPR39TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113651811-B | Isoxazole-containing pyridopyrimidone compound and preparation method and application thereof | 贵州大学 | 2022-06-07 | — | — | CN | disclosed |