Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245353 | 0.83 | SLC18A3 (0.56) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL9665275 | 0.83 | SLC18A3 (0.56) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL9768803 | 0.82 | ALDH1A1 (0.49) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL2427999 | 0.82 | SLC18A3 (0.52) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL5046019 | 0.82 | SLC18A3 (0.54) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL9668119 | 0.82 | SLC18A3 (0.54) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL7447435 | 0.80 | SLC18A3 (0.58) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL9016165 | 0.75 | KDM4E (0.50) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL9016167 | 0.74 | KDM4E (0.49) | SLC18A3ALDH1A1APPGAAHCAR3 | |
| SCHEMBL7241178 | 0.74 | CHRNB2 (0.48) | SLC18A3ALDH1A1APPGAAHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478528-A | Aroyl-substituted tricyclic compound, preparation method and application thereof | 劲方医药科技(上海)有限公司 | 2022-05-13 | — | — | CN | disclosed |