Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622179 | 0.82 | KMT2A (0.44) | SCN4AKEAP1KMT2APDE4APDE4B | |
| SCHEMBL14277965 | 0.81 | KEAP1 (0.53) | SCN4AKEAP1KMT2ACYP19A1PIK3CD | |
| SCHEMBL29133162 | 0.81 | KEAP1 (0.46) | SCN4AKEAP1KMT2APDE4APDE4B | |
| SCHEMBL29598492 | 0.81 | KMO (0.48) | SCN4AKEAP1KMT2APDE4APDE4B | |
| SCHEMBL17049238 | 0.81 | ALDH1A1 (0.59) | SCN4AKEAP1KMT2APDE4APDE4B | |
| SCHEMBL16910765 | 0.79 | KDM4E (0.50) | SCN4AKEAP1KMT2ACYP19A1PIK3CD | |
| SCHEMBL29598874 | 0.78 | KCNH2 (0.53) | SCN4AKEAP1KMT2ACYP19A1PIK3CD | |
| SCHEMBL27762793 | 0.78 | KMT2A (0.48) | SCN4AKEAP1KMT2ABRD4FYN | |
| SCHEMBL29101338 | 0.78 | PDE4A (0.40) | KDM1AKMT2APDE4APDE4BPDE4C | |
| SCHEMBL16627912 | 0.77 | KMO (0.48) | SCN4AKEAP1KMT2ACYP19A1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11304929-B2 | Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11304929-B2 | Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors | PHGDH, G6PD, PHPT1 | SCN4A 3307/4885KEAP1 1378/4885KDM1A 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.