Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16205315 | 1.00 | PRKCI (0.53) | PRKCICYP2A6KCNH2KIF11CHRNA7 | |
| SCHEMBL3995631 | 0.85 | HTR7 (0.49) | PRKCICYP2A6KIF11PIK3CBHTR7 | |
| SCHEMBL2627061 | 0.82 | PRKCI (0.55) | PRKCICYP2A6KCNH2PIK3CBHSD11B1 | |
| SCHEMBL18857011 | 0.78 | KRAS (0.44) | KCNH2HTR7HTR2C | |
| SCHEMBL18856953 | 0.78 | HTR7 (0.47) | KCNH2HTR7KDM4EHTR2C | |
| SCHEMBL16619618 | 0.77 | CA2 (0.52) | KCNH2KDM4EPKMCYP11B1CYP11B2 | |
| SCHEMBL22388515 | 0.77 | PRKCI (0.49) | PRKCICYP2A6KCNH2CHRNA7PIK3CB | |
| SCHEMBL20655579 | 0.77 | ALDH1A1 (0.44) | KCNH2KIF11HTR7PKMCYP11B1 | |
| SCHEMBL22803948 | 0.76 | HTR2B (0.59) | MAOBKDM4ETP53CYP1A2CYP3A4 | |
| SCHEMBL4940378 | 0.75 | CYP2A6 (0.44) | CYP2A6KIF11HSD11B1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322132-A | N-substituted indole compound and synthetic method thereof | 陕西科技大学 | 2022-11-11 | — | — | CN | disclosed |
| US-11304929-B2 | Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11304929-B2 | Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors | PHGDH, G6PD, PHPT1 | PRKCI 1364/4885CYP2A6 473/4885KCNH2 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.