Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.74 |
| ▸ | DRD2 | P14416 | 2/20 | 0.74 |
| ▸ | DRD1 | P21728 | 2/20 | 0.74 |
| ▸ | DRD4 | P21917 | 2/20 | 0.74 |
| ▸ | DRD5 | P21918 | 2/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.74 |
| ▸ | DRD3 | P35462 | 2/20 | 0.74 |
| ▸ | RECQL | P46063 | 2/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | BLM | P54132 | 2/20 | 0.74 |
| ▸ | GFER | P55789 | 2/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL50427 | 0.98 | ALOX15 (0.73) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL29435413 | 0.98 | ALOX15 (0.73) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL29456593 | 0.86 | ALOX15 (0.73) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL50897 | 0.86 | ALOX15 (0.73) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL23704750 | 0.85 | KDM4E (1.00) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL29831984 | 0.85 | KDM4E (1.00) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL3954271 | 0.85 | KDM4E (1.00) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL29636832 | 0.85 | KDM4E (1.00) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL30379446 | 0.85 | KDM4E (1.00) | MAPTKDM4ELMNAMAPK1ADRA2A | |
| Dopamine SCHEMBL40952 | 0.85 | KDM4E (1.00) | MAPTKDM4ELMNAMAPK1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116173227-A | Targeted magnetic nano-composite of palygorskite, preparation method and application thereof in preparation of in-vitro drug controlled release drug | 淮阴师范学院 | 2023-05-30 | — | — | CN | claimed |
| CN-113881040-B | Preparation method and application of two-dimensional MXene/polydopamine composite desalting electrode material | 上海交通大学 | 2022-05-31 | — | — | CN | claimed |
| CN-116327932-A | Preparation method and application of pH response type bionic gold nano-drug for chemotherapy, thermotherapy and targeted therapy | 河南大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-116173227-A | Targeted magnetic nano-composite of palygorskite, preparation method and application thereof in preparation of in-vitro drug controlled release drug | 淮阴师范学院 | 2023-05-30 | — | — | CN | disclosed |