Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 10/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24397909 | 1.00 | HDAC1 (0.40) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL24801664 | 0.90 | HDAC1 (0.39) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL24801647 | 0.88 | HDAC1 (0.38) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL24397807 | 0.88 | SLC6A2 (0.36) | TRPV1 | |
| SCHEMBL29601371 | 0.88 | SLC6A2 (0.36) | TRPV1 | |
| SCHEMBL24398054 | 0.85 | — | — | |
| SCHEMBL25043232 | 0.84 | HDAC1 (0.40) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL24394104 | 0.82 | THRB (0.37) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL24397872 | 0.80 | SLC6A3 (0.39) | HDAC1HDAC3HDAC2HDAC6PDE2A | |
| SCHEMBL24397786 | 0.80 | APP (0.38) | PDE2AAPPKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359390-A1 | ACRYLAMIDE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | Sitryx Therapeutics Limited (GB) | 2024-05-01 | — | — | EP | disclosed |
| EP-4237404-A1 | NOVEL COMPOUNDS | Sitryx Therapeutics Limited (GB) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022269251-A1 | ACRYLAMIDE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | SITRYX THERAPEUTICS LIMITED (GB) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022090724-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LIMITED (GB) | 2022-05-05 | — | — | WO | disclosed |