Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29615773 | 0.88 | ADORA3 (0.50) | ADORA3ADORA2AADORA1KLK6KDM4E | |
| SCHEMBL31458675 | 0.86 | ADORA3 (0.48) | ADORA3ADORA2AADORA1KLK6KDM4E | |
| SCHEMBL23495801 | 0.71 | KDM4E (0.41) | ADORA3ADORA2AADORA1KDM4EL3MBTL1 | |
| SCHEMBL12266002 | 0.71 | KDM4E (0.41) | MYCKDM4EL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL29600787 | 0.71 | KDM4E (0.41) | ADORA3ADORA2AADORA1KDM4EL3MBTL1 | |
| SCHEMBL30976294 | 0.69 | KAT2B (0.46) | KDM4EL3MBTL1ALDH1A1TET2TET1 | |
| SCHEMBL15197861 | 0.68 | SSTR4 (0.42) | MYCKDM4EL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL4550466 | 0.66 | KDM4C (0.52) | MYCKDM4EL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL29615760 | 0.66 | ADORA3 (0.49) | ADORA3ADORA2AADORA1PARP1GRM4 | |
| SCHEMBL29824628 | 0.66 | GABRA1 (0.40) | ADORA3ADORA2AADORA1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250011327-A1 | TRICYCLIC COMPOUNDS | JACOBIO PHARMACEUTICALS CO LTD (CN) | 2025-01-09 | — | — | US | disclosed |
| US-12103929-B2 | Tricyclic compounds | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-10-01 | — | — | US | disclosed |
| US-11466005-B2 | Tricyclic compounds | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-10-11 | — | — | US | disclosed |
| CN-115109061-A | Tricyclic compounds | 北京加科思新药研发有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-112513041-B | Tricyclic compounds | 北京加科思新药研发有限公司 | 2022-05-10 | — | — | CN | disclosed |
| US-20220119390-A1 | TRICYCLIC COMPOUNDS | JACOBIO PHARMACEUTICALS CO LTD (CN) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250011327-A1 | TRICYCLIC COMPOUNDS | BRD4, BET1, BRD3 | ADORA3 4688/4885ADORA2A 4671/4885ADORA1 4649/4885 |
| US-11466005-B2 | Tricyclic compounds | BRD4, BET1, BRD3 | ADORA3 4688/4885ADORA2A 4671/4885ADORA1 4649/4885 |
| US-12103929-B2 | Tricyclic compounds | BRD4, BET1, BRD3 | ADORA3 4688/4885ADORA2A 4671/4885ADORA1 4649/4885 |
| US-20220119390-A1 | TRICYCLIC COMPOUNDS | BRD4, BET1, BRD3 | ADORA3 4688/4885ADORA2A 4671/4885ADORA1 4649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.