Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495801 | 1.00 | KDM4E (0.41) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL23495642 | 0.87 | JAK2 (0.41) | KDM4EADORA3ADORA2AADORA1PARP1 | |
| SCHEMBL29600778 | 0.83 | KDM4E (0.50) | KDM4EMAPTALDH1A1L3MBTL1ADORA3 | |
| SCHEMBL5315944 | 0.79 | GRM4 (0.49) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL31133393 | 0.79 | GRM4 (0.49) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL29824628 | 0.76 | GABRA1 (0.40) | KDM4EALDH1A1L3MBTL1ADORA3ADORA2A | |
| SCHEMBL23495733 | 0.74 | NUDT1 (0.43) | KDM4ECYP3A4ADORA3ADORA2AADORA1 | |
| SCHEMBL23495746 | 0.72 | CA1 (0.40) | KDM4EADORA3ADORA2AADORA1PARP1 | |
| SCHEMBL29601219 | 0.71 | ADORA3 (0.51) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL5264143 | 0.71 | DYRK1A (0.43) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115109061-A | Tricyclic compounds | 北京加科思新药研发有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-112513041-B | Tricyclic compounds | 北京加科思新药研发有限公司 | 2022-05-10 | — | — | CN | disclosed |