Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20754976 | 0.83 | HTR7 (0.42) | SMN1; SMN2MEN1KMT2ATRPM8ALDH1A1 | |
| SCHEMBL70767 | 0.78 | L3MBTL1 (0.41) | HCRTR1HCRTR2SMN1; SMN2TRPM8KDM4E | |
| SCHEMBL698991 | 0.78 | L3MBTL1 (0.55) | HCRTR1HCRTR2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3488783 | 0.78 | TRPM8 (0.45) | TRPM8KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL569266 | 0.77 | TRPM8 (0.40) | KMT2ATRPM8KDM4EALDH1A1 | |
| SCHEMBL7072815 | 0.77 | KDM4E (0.40) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3488694 | 0.77 | NFE2L2 (0.46) | HCRTR1HCRTR2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2893762 | 0.77 | L3MBTL1 (0.40) | HCRTR1HCRTR2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8986031 | 0.76 | MEN1 (0.69) | SMN1; SMN2MEN1KMT2ATRPM8KDM4E | |
| SCHEMBL6902624 | 0.76 | KDM4E (0.46) | HCRTR1HCRTR2SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |