Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22583484 | 1.00 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL22583092 | 0.85 | ALDH1A1 (0.42) | ALDH1A1GAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL22583033 | 0.83 | KMT2A (0.37) | ALDH1A1GAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL29435582 | 0.83 | KMT2A (0.37) | ALDH1A1GAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL29601685 | 0.82 | MEN1 (0.39) | ALDH1A1GAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL22583490 | 0.80 | CACNA1G (0.34) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL22583020 | 0.80 | ALDH1A1 (0.38) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL29435524 | 0.80 | ALDH1A1 (0.41) | ALDH1A1GAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL22583372 | 0.80 | ALDH1A1 (0.41) | ALDH1A1GAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL29435771 | 0.78 | RAF1 (0.36) | ALDH1A1MAPK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |