Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.60 |
| ▸ | TEAD4 | Q15561 | 3/20 | 0.50 |
| ▸ | TEAD2 | Q15562 | 3/20 | 0.50 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.50 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | IDH2 | P48735 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718324 | 1.00 | MPO (0.60) | MPOTEAD4TEAD2TEAD1TEAD3 | |
| SCHEMBL21764739 | 0.83 | ALDH1A1 (0.61) | TEAD4TEAD2TEAD1TEAD3ALDH1A1 | |
| SCHEMBL22719490 | 0.76 | MPO (0.60) | MPOTEAD1ALDH1A1GAAMAPT | |
| SCHEMBL22719803 | 0.76 | MPO (0.60) | MPOTEAD4TEAD2ALDH1A1GAA | |
| SCHEMBL29504957 | 0.76 | MPO (0.60) | MPOTEAD1ALDH1A1GAAMAPT | |
| SCHEMBL27747543 | 0.76 | MPO (0.58) | MPOALDH1A1GAAMAPTRAB9A | |
| SCHEMBL1688342 | 0.75 | MPO (1.00) | MPOTEAD4TEAD2ALDH1A1GRIK1 | |
| SCHEMBL29504999 | 0.74 | MPO (0.79) | MPOTEAD4TEAD2GRIK1RXFP1 | |
| SCHEMBL22719560 | 0.74 | MPO (0.79) | MPOTEAD4TEAD2GRIK1RXFP1 | |
| SCHEMBL26126952 | 0.73 | TAS2R14 (0.52) | MPOTEAD4TEAD2TEAD1TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-114466839-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2022-05-10 | — | — | CN | disclosed |