Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 4/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20774145 | 0.90 | TAAR1 (0.40) | HINT1TAAR1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL20774144 | 0.90 | TAAR1 (0.40) | HINT1TAAR1GSK3ARPS6KA3MAPK14 | |
| SCHEMBL23326714 | 0.83 | STING1 (0.41) | TAAR1STING1PDE3BPDE3A | |
| SCHEMBL23351365 | 0.78 | CYP3A4 (0.33) | — | |
| SCHEMBL12729604 | 0.77 | STING1 (0.46) | STING1POLBPDE3BPDE3A | |
| SCHEMBL8620596 | 0.77 | STING1 (0.46) | STING1POLBPDE3BPDE3A | |
| SCHEMBL23326436 | 0.76 | LMNA (0.36) | — | |
| SCHEMBL23326433 | 0.76 | LMNA (0.36) | — | |
| SCHEMBL22983981 | 0.74 | STING1 (0.60) | STING1PDE3BPDE3A | |
| SCHEMBL9964274 | 0.74 | STING1 (0.60) | STING1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11267844-B2 | Spirothietane nucleosides | JANSSEN PHARMACEUTICA NV (BE) | 2022-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11267844-B2 | Spirothietane nucleosides | SAMHD1, SLC28A1, SLC28A2 | HINT1 1306/4885TAAR1 2623/4885GSK3A 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.