Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21331983 | 0.88 | MAPK7 (0.48) | MAPK7KDM4EMAPTTHRBGPR119 | |
| SCHEMBL21332047 | 0.86 | MAPK7 (0.64) | MAPK7KDM4EMAPTTHRBGPR119 | |
| SCHEMBL29611832 | 0.86 | PIK3CD (0.41) | MAPK7GPR119HPGDSFNTAFNTB | |
| SCHEMBL21339642 | 0.83 | MAPK7 (0.65) | MAPK7KDM4EMAPTTHRBGPR119 | |
| SCHEMBL29611125 | 0.81 | MAPK7 (0.54) | MAPK7KDM4EMAPTTHRBGPR119 | |
| SCHEMBL16637780 | 0.77 | MAPK7 (0.47) | MAPK7KDM4EMAPTTHRBGPR119 | |
| SCHEMBL30186806 | 0.77 | HCAR1 (0.52) | KDM4EMAPTTHRBGPR119FNTA | |
| SCHEMBL24312866 | 0.77 | GPR119 (0.57) | KDM4EMAPTTHRBGPR119HPGDS | |
| SCHEMBL3568241 | 0.76 | MAPK7 (0.52) | MAPK7KDM4EMAPTTHRBGPR119 | |
| SCHEMBL21332138 | 0.76 | MAPK7 (0.62) | MAPK7KDM4EMAPTTHRBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022051565-A1 | SUBSTITUTED 4-PIPERIDINYL-QUINAZOLINES, 4-PIPERIDINYL-PYRIMIDINE-2-AMINES, AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2022-03-10 | — | — | WO | disclosed |