Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29611488 | 0.86 | MAPK7 (0.48) | FNTAFNTBMAPK7GPR119MAP4K4 | |
| SCHEMBL29611184 | 0.84 | MAPK7 (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGMAPK7 | |
| SCHEMBL21332047 | 0.75 | MAPK7 (0.64) | MAPK7GPR119 | |
| SCHEMBL21331983 | 0.74 | MAPK7 (0.48) | MAPK7GPR119MAP4K4HPGDS | |
| SCHEMBL30366132 | 0.72 | USP30 (0.42) | PIK3CDGPR119USP30 | |
| SCHEMBL30186806 | 0.72 | HCAR1 (0.52) | FNTAFNTBGPR119 | |
| SCHEMBL30899638 | 0.72 | USP30 (0.46) | PIK3CDGPR119USP30HPGDS | |
| SCHEMBL29611192 | 0.70 | USP30 (0.46) | PIK3CDIDO1TDO2GPR119USP30 | |
| SCHEMBL21339642 | 0.70 | MAPK7 (0.65) | MAPK7GPR119MAP4K4 | |
| SCHEMBL12847405 | 0.69 | GPR119 (0.50) | IDO1TDO2GPR119USP30HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022051565-A1 | SUBSTITUTED 4-PIPERIDINYL-QUINAZOLINES, 4-PIPERIDINYL-PYRIMIDINE-2-AMINES, AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2022-03-10 | — | — | WO | disclosed |