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Sugi Predict / Compounds / SCHEMBL29611544

SCHEMBL29611544

SCHEMBL29611544

COc1ccc(CNc2ncnc3c2c(C2=CCCC2)cn3[C@@H]2O[C@H](C(=O)NC3CCN(C)CC3)[C@H]3OC(C)(C)O[C@H]32)c(OC)c1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 14/20 0.40
▸ PRMT5 O14744 13/20 0.40
▸ WDR77 Q9BQA1 13/20 0.40
▸ ADORA3 P0DMS8 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24313841 1.00 METTL3 (0.40) METTL3PRMT5WDR77ADORA3
SCHEMBL24313535 0.88 ADORA3 (0.40) METTL3PRMT5WDR77ADORA3
SCHEMBL29610818 0.88 ADORA3 (0.40) METTL3PRMT5WDR77ADORA3
SCHEMBL29611642 0.88 METTL3 (0.49) METTL3PRMT5WDR77ADORA3
SCHEMBL24313846 0.88 METTL3 (0.49) METTL3PRMT5WDR77ADORA3
SCHEMBL24313534 0.87 METTL3 (0.58) METTL3PRMT5WDR77
SCHEMBL29610932 0.87 METTL3 (0.58) METTL3PRMT5WDR77
SCHEMBL24313688 0.86 METTL3 (0.52) METTL3PRMT5WDR77ADORA3
SCHEMBL29611650 0.86 METTL3 (0.52) METTL3PRMT5WDR77ADORA3
SCHEMBL27090415 0.85 METTL3 (0.47) METTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4229067-A1 METTL3 MODULATORS Accent Therapeutics, Inc. (US) 2023-08-23 — — EP disclosed
WO-2022081739-A1 METTL3 MODULATORS ACCENT THERAPEUTICS, INC. (US) 2022-04-21 — — WO disclosed
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