Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | NCF1 | P14598 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCK1 | P16333 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23062670 | 1.00 | KDM4E (0.53) | KDM4EPOLBLMNACASP6CYP1A2 | |
| SCHEMBL23042415 | 0.80 | HTT (0.43) | KDM4EPOLBLMNACASP6CYP1A2 | |
| SCHEMBL29612747 | 0.79 | NCF1 (0.35) | NCF1CYP3A4PPARGBACE1TEC | |
| SCHEMBL23062649 | 0.79 | NCF1 (0.35) | NCF1CYP3A4PPARGBACE1TEC | |
| SCHEMBL3141130 | 0.78 | THRB (0.57) | — | |
| SCHEMBL23061561 | 0.78 | PPARG (0.41) | KDM4EPOLBCYP1A2CYP3A4PPARG | |
| SCHEMBL29612505 | 0.78 | PPARG (0.41) | KDM4EPOLBCYP1A2CYP3A4PPARG | |
| SCHEMBL23063015 | 0.77 | PPARG (0.56) | KDM4EPOLBCASP6CYP3A4PPARG | |
| SCHEMBL29612552 | 0.77 | PPARG (0.56) | KDM4EPOLBCASP6CYP3A4PPARG | |
| SCHEMBL11292862 | 0.77 | HTT (0.53) | KDM4ELMNACYP1A2CYP3A4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017875-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114430743-A | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2022-05-03 | — | — | CN | disclosed |