Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 11/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.39 |
| ▸ | CNR1 | P21554 | 7/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28730693 | 1.00 | CNR2 (0.39) | CNR2ACHECNR1DGAT1MAPT | |
| SCHEMBL28730654 | 0.89 | MAPT (0.35) | CNR2ACHECNR1DGAT1MAPT | |
| SCHEMBL29612490 | 0.89 | MAPT (0.35) | CNR2ACHECNR1DGAT1MAPT | |
| SCHEMBL23042371 | 0.88 | CNR1 (0.34) | CNR2ACHECNR1DGAT1MAPT | |
| SCHEMBL23042317 | 0.86 | DGAT1 (0.34) | CNR2ACHECNR1DGAT1 | |
| SCHEMBL29612547 | 0.83 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL23042376 | 0.76 | PKM (0.41) | MAPTSMN1; SMN2HPGDLMNAKDM4E | |
| SCHEMBL23042395 | 0.76 | MEN1 (0.33) | MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL23042580 | 0.76 | THRB (0.48) | — | |
| SCHEMBL29612454 | 0.74 | PTPN1 (0.34) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017875-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns Pharmaceuticals, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114430743-A | Thyroid hormone receptor beta agonist compounds | 拓臻制药公司 | 2022-05-03 | — | — | CN | disclosed |