Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11550702 | 0.86 | GUSB (0.42) | PLA2G4BPOLBMAPTTP53TDP1 | |
| SCHEMBL11552873 | 0.77 | PDE5A (0.44) | PLA2G4BPOLBMAPTTP53TDP1 | |
| SCHEMBL11556538 | 0.77 | TSHR (0.47) | POLBMAPTTP53TDP1NPC1 | |
| SCHEMBL11552844 | 0.72 | GUSB (0.49) | POLBMAPTTP53TDP1NPC1 | |
| SCHEMBL11554058 | 0.71 | GUSB (0.51) | POLBMAPTTP53TDP1NPC1 | |
| SCHEMBL11375670 | 0.71 | GUSB (0.56) | POLBMAPTTP53TDP1TSHR | |
| SCHEMBL11554449 | 0.71 | GUSB (0.47) | POLBMAPTTP53TDP1NPC1 | |
| SCHEMBL11550692 | 0.70 | LMNA (0.43) | POLBMAPTTP53TDP1NPC1 | |
| SCHEMBL11373870 | 0.70 | GUSB (0.55) | PDE3BPDE3AP2RY12CHEK2RARB | |
| SCHEMBL11549969 | 0.70 | GUSB (0.49) | PLA2G4BPOLBMAPTTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828150-B1 | PROCESSES FOR PRODUCING 4-AMINOQUINAZOLINES | VERTEX PHARMA (US) | 2012-03-14 | — | — | EP | disclosed |