Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Diethylene Glycol Monoethyl Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triethylene Glycol SCHEMBL2959242 | 1.00 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Succinic Acid SCHEMBL2960825 | 0.93 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Adipic Acid SCHEMBL2954452 | 0.92 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ATSHRTHRB | |
| Diethylene Glycol Monoethyl Ether SCHEMBL28088918 | 0.92 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Adipic Acid SCHEMBL2964088 | 0.92 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ATSHRTHRB | |
| Succinic Acid SCHEMBL1234712 | 0.91 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ATSHRTHRB | |
| Succinic Acid SCHEMBL4803598 | 0.89 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2ATSHRTHRB | |
| Triethylene Glycol SCHEMBL1815430 | 0.89 | MEN1 (0.61) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Tetraethylene Glycol SCHEMBL15049107 | 0.89 | MEN1 (0.61) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Succinic Acid SCHEMBL2958838 | 0.87 | MEN1 (0.48) | ALDH1A1MEN1KMT2ATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392314-B1 | OILY HAIR COSMETIC | KOKYU ALCOHOL KOGYO CO LTD (JP) | 2019-08-14 | — | — | EP | claimed |
| EP-2392314-B1 | OILY HAIR COSMETIC | KOKYU ALCOHOL KOGYO CO LTD (JP) | 2019-08-14 | — | — | EP | disclosed |
| US-8562957-B2 | Oily hair cosmetics | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2013-10-22 | — | — | US | disclosed |
| US-20100203003-A1 | Oily Hair Cosmetics | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2010-08-12 | — | — | US | disclosed |
| US-7766978-B2 | Acidic hair dyeing method | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20090100609-A1 | ACIDIC HAIR DYE COMPOSITION | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090100609-A1 | ACIDIC HAIR DYE COMPOSITION | H1-0, MRM1, H1-4 | ALDH1A1 81/4885MEN1 157/4885KMT2A 2163/4885 |
| US-20100203003-A1 | Oily Hair Cosmetics | H1-0, H1-2, H1-3 | ALDH1A1 2116/4885MEN1 85/4885KMT2A 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.