Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22919001 | 1.00 | LTA4H (0.57) | LTA4HPTGS2PTGS1CHRNB2CHRNA4 | |
| SCHEMBL22918728 | 0.97 | LTA4H (0.54) | LTA4HPTGS2PTGS1CHRNB2CHRNA4 | |
| SCHEMBL29615365 | 0.97 | LTA4H (0.54) | LTA4HPTGS2PTGS1CHRNB2CHRNA4 | |
| SCHEMBL22918759 | 0.92 | HRH3 (0.54) | KDM4E | |
| SCHEMBL29615450 | 0.92 | HRH3 (0.54) | KDM4E | |
| SCHEMBL2023773 | 0.88 | MEN1 (0.55) | LTA4HKDM4EALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL29615193 | 0.87 | KDM4E (0.58) | LTA4HKDM4EALDH1A1KMT2A | |
| SCHEMBL2024990 | 0.87 | KDM4E (0.58) | LTA4HKDM4EALDH1A1KMT2A | |
| SCHEMBL2029749 | 0.83 | MAOA (0.45) | LTA4HKDM4EALDH1A1SMN1; SMN2PSMB1 | |
| SCHEMBL23976303 | 0.81 | LTA4H (0.57) | LTA4HPTGS2CHRNB2CHRNA4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003992-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL) -PYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174293-A | 4- (imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2022-03-11 | — | — | CN | disclosed |