Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | CXCR5 | P32302 | 3/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12715536 | 0.80 | POLB (0.46) | PNMTDRD2DRD3KDM1ACXCR5 | |
| SCHEMBL29506141 | 0.74 | PNMT (0.49) | PNMTDRD2DRD3KDM1A | |
| SCHEMBL22789739 | 0.74 | PNMT (0.49) | PNMTDRD2DRD3KDM1A | |
| SCHEMBL24878784 | 0.72 | DRD2 (0.43) | PNMTDRD2DRD3KDM1A | |
| SCHEMBL27795984 | 0.72 | CXCR5 (0.47) | PNMTDRD2DRD3KDM1ACXCR5 | |
| SCHEMBL6739755 | 0.72 | — | — | |
| SCHEMBL24878782 | 0.71 | HRH3 (0.42) | PNMTDRD2DRD3KDM1ACXCR5 | |
| SCHEMBL18710410 | 0.71 | EPAS1 (0.30) | — | |
| SCHEMBL24275671 | 0.70 | TDP2 (0.41) | PNMTKDM1A | |
| Bromide SCHEMBL17202846 | 0.70 | PNMT (0.52) | PNMTDRD2DRD3KDM1ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022121805-A1 | FUSED RING COMPOUND AS NAV1.8 INHIBITOR AND USE THEREOF | 成都康弘药业集团股份有限公司 | 2022-06-16 | — | — | WO | disclosed |
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |