Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29130900 | 0.88 | POLB (0.64) | POLBSMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL31184625 | 0.85 | POLB (0.49) | POLBSMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL22000031 | 0.82 | POLB (0.64) | POLBSMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL23033513 | 0.81 | POLB (0.62) | POLBSMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL2348940 | 0.80 | MEN1 (0.63) | SMN1; SMN2LMNAHPGDHTTMEN1 | |
| SCHEMBL3997305 | 0.80 | LMNA (0.66) | POLBSMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL30355120 | 0.80 | LMNA (0.66) | POLBSMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL4242416 | 0.78 | POLB (0.62) | POLBSMN1; SMN2HPGDMALT1ACHE | |
| SCHEMBL8901878 | 0.78 | POLB (0.62) | POLBSMN1; SMN2HPGDMALT1ACHE | |
| SCHEMBL30870166 | 0.77 | POLB (0.64) | POLBSMN1; SMN2LMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |