Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 4/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 4/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461305 | 0.88 | SMARCA2 (0.66) | SMARCA2SMARCA4PBRM1KITPDK2 | |
| SCHEMBL29619458 | 0.82 | EGLN2 (0.39) | SMARCA2SMARCA4PBRM1CYP11B2PARP1 | |
| SCHEMBL27063427 | 0.80 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1PARP1KIT | |
| SCHEMBL24461312 | 0.80 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1NAMPTTERT | |
| SCHEMBL29619413 | 0.80 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1NAMPTTERT | |
| SCHEMBL29619435 | 0.80 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1PARP1KIT | |
| SCHEMBL31293622 | 0.79 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1CYP11B2PARP1 | |
| SCHEMBL30666247 | 0.78 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1CYP11B2PARP1 | |
| SCHEMBL26683498 | 0.78 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1CYP11B2PARP1 | |
| SCHEMBL27053067 | 0.78 | PBRM1 (0.42) | SMARCA2SMARCA4PBRM1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |