Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296857 | 0.87 | GABRA5 (0.43) | NTRK1GABRA5GABRA1SCDSCD5 | |
| SCHEMBL296331 | 0.84 | GABRA5 (0.47) | GABRA5 | |
| SCHEMBL296387 | 0.83 | GABRA5 (0.40) | GABRA5ITGA5 | |
| SCHEMBL297942 | 0.83 | GABRA5 (0.41) | GABRA5SCDSCD5 | |
| SCHEMBL296194 | 0.81 | GABRA5 (0.43) | GABRA5GABRA1ITGA5 | |
| SCHEMBL295361 | 0.79 | ALDH1A1 (0.41) | GABRA5 | |
| SCHEMBL296673 | 0.71 | GABRA5 (0.41) | NTRK1GABRA5 | |
| SCHEMBL297987 | 0.70 | GABRA5 (0.38) | GABRA5GABRA1SCDSCD5 | |
| SCHEMBL297419 | 0.70 | GABRA5 (0.42) | GABRA5 | |
| SCHEMBL298195 | 0.70 | GABRA5 (0.46) | GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163728-B2 | Pyrazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | claimed |
| US-20100286115-A1 | PYRAZOLES | ROCHE PALO ALTO LLC | 2010-11-11 | — | — | US | claimed |
| US-8163728-B2 | Pyrazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127975-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| US-20100286115-A1 | PYRAZOLES | ROCHE PALO ALTO LLC | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286115-A1 | PYRAZOLES | GABRA5, GABRA1, GABRA3 | NTRK1 972/4885GABRA5 1/4885GABRA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.