SCHEMBL29619913

SCHEMBL29619913

COc1ccc2oc3ccc(OC)cc3c(=O)c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
NPC1 O15118 6/20 1.00
KDM4E B2RXH2 5/20 1.00
RAB9A P51151 5/20 1.00
HPGD P15428 5/20 1.00
MAPT P10636 4/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
CASP3 P42574 1/20 1.00
SENP8 Q96LD8 1/20 1.00
SENP7 Q9BQF6 1/20 1.00
SENP6 Q9GZR1 1/20 1.00
MAOA P21397 2/20 0.83
HSD17B10 Q99714 3/20 0.64
MAPK1 P28482 1/20 0.62
CYP3A4 P08684 2/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C9 P11712 1/20 0.60
TSHR P16473 1/20 0.60
CYP2C19 P33261 1/20 0.60
TDP1 Q9NUW8 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2161251 1.00 ALDH1A1 (1.00) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL7331388 0.93 KDM4E (0.86) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL16477276 0.91 MAPT (0.83) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL394209 0.91 MAOA (1.00) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL24688956 0.90 ALDH1A1 (0.81) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL16480054 0.90 KDM4E (0.81) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL570670 0.90 KDM4E (0.81) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL20317207 0.88 NPC1 (0.78) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL20329616 0.88 KDM4E (0.78) ALDH1A1NPC1KDM4ERAB9AHPGD
SCHEMBL20329731 0.88 KDM4E (0.78) ALDH1A1NPC1KDM4ERAB9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022088911-A1 BENZOPHENANTHRENE DERIVATIVE AND APPLICATION THEREOF 北京八亿时空液晶科技股份有限公司 2022-05-05 WO disclosed