Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18992619 | 0.83 | DDB1 (0.33) | DDB1CRBNGSK3BALDH1A1KDM4E | |
| SCHEMBL18992892 | 0.76 | JAK2 (0.32) | GSK3BOPRM1MAPT | |
| SCHEMBL5951384 | 0.76 | ALDH1A1 (0.43) | DDB1CRBNGSK3BALDH1A1KDM4E | |
| SCHEMBL18992620 | 0.75 | DDB1 (0.33) | DDB1CRBNGSK3BALDH1A1KDM4E | |
| SCHEMBL14363466 | 0.73 | ALDH1A1 (0.41) | DDB1CRBNGSK3BALDH1A1KDM4E | |
| SCHEMBL30459575 | 0.72 | ALDH1A1 (0.40) | DDB1CRBNGSK3BALDH1A1KDM4E | |
| SCHEMBL14862969 | 0.71 | ALDH1A1 (0.42) | DDB1CRBNGSK3BALDH1A1KDM4E | |
| SCHEMBL23666072 | 0.71 | OPRM1 (0.38) | DDB1CRBNALDH1A1KDM4EOPRM1 | |
| SCHEMBL18992893 | 0.70 | MAPT (0.34) | DDB1CRBNOPRM1MAPTPDE10A | |
| SCHEMBL12613616 | 0.69 | OPRM1 (0.39) | DDB1CRBNALDH1A1KDM4EOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11931350-B2 | Opioid receptor ligands and methods of using and making same | TREVENA, INC. (US) | 2024-03-19 | — | — | US | disclosed |
| US-20220175747-A1 | Opioid Receptor Ligands And Methods Of Using And Making Same | TREVENA, INC. | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175747-A1 | Opioid Receptor Ligands And Methods Of Using And Making Same | OPRL1, OPRK1, OPRM1 | DDB1 4618/4885CRBN 4498/4885GSK3B 3631/4885 |
| US-11931350-B2 | Opioid receptor ligands and methods of using and making same | OPRL1, OPRK1, OPRM1 | DDB1 4618/4885CRBN 4498/4885GSK3B 3631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.