Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1347929 | 0.90 | ALDH1A1 (0.56) | LTA4HALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL20767529 | 0.87 | LTA4H (0.53) | LTA4HALDH1A1MTNR1AMTNR1BTRIM24 | |
| SCHEMBL20767500 | 0.83 | MAOB (0.56) | ERN1LMNAMEN1POLBMAPT | |
| SCHEMBL30117588 | 0.82 | CALM1 (0.48) | ALDH1A1TRIM24TYRTRIM33ERN1 | |
| SCHEMBL2474493 | 0.81 | MEN1 (0.49) | ALDH1A1MTNR1AMTNR1BGPR55LMNA | |
| SCHEMBL29414471 | 0.81 | ALDH1A1 (0.61) | ALDH1A1TRIM24TYRTRIM33ERN1 | |
| SCHEMBL15935610 | 0.81 | ALDH1A1 (0.61) | ALDH1A1TRIM24TYRTRIM33ERN1 | |
| SCHEMBL3895840 | 0.81 | FBP1 (0.50) | LTA4HALDH1A1MTNR1AMTNR1BGPR55 | |
| SCHEMBL29051924 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MTNR1AMTNR1BTRIM24TYR | |
| SCHEMBL3895846 | 0.81 | FBP1 (0.50) | LTA4HALDH1A1MTNR1AMTNR1BGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257027-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS (US) | 2025-08-14 | — | — | US | disclosed |
| US-12269798-B2 | Second generation GRP94-selective inhibitors | UNIVERSITY OF KANSAS (US) | 2025-04-08 | — | — | US | disclosed |
| WO-2023109273-A1 | METHOD FOR PREPARING ANTI-HIV DRUG ISLATRAVIR | 福建瑞博奥科技有限公司 | 2023-06-22 | — | — | WO | disclosed |
| US-20210300872-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2021-09-30 | — | — | US | disclosed |
| US-20210300872-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2021-09-30 | — | — | US | disclosed |
| US-11028041-B2 | Second generation GRP94-selective inhibitors | UNIVERSITY OF KANSAS (US) | 2021-06-08 | — | — | US | disclosed |
| US-11028041-B2 | Second generation GRP94-selective inhibitors | UNIVERSITY OF KANSAS (US) | 2021-06-08 | — | — | US | disclosed |
| US-20200190017-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2020-06-18 | — | — | US | disclosed |
| US-20200190017-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS | 2020-06-18 | — | — | US | disclosed |
| CN-107216269-B | Hydroxylating phenanthroline copper complex/O2The method of catalysis oxidation alkohol and amine cross-coupling synthesizing imine | 山西师范大学 | 2019-06-04 | — | — | CN | disclosed |
| WO-2019040792-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2019040792-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | UNIVERSITY OF KANSAS (US) | 2019-02-28 | — | — | WO | disclosed |
| US-7776867-B2 | Furanopyrimidines | AMGEN INC. (US) | 2010-08-17 | — | — | US | disclosed |
| EP-1768986-A2 | FURANOPYRIMIDINES | Amgen Inc. (US) | 2007-04-04 | — | — | EP | disclosed |
| US-20060040961-A1 | Furanopyrimidines | AMGEN INC. | 2006-02-23 | — | — | US | disclosed |
| WO-2006004658-A2 | FURANOPYRIMIDINES | AMGEN INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12269798-B2 | Second generation GRP94-selective inhibitors | HSP90B1, HSP90AB2P, HSPE1 | LTA4H 3870/4885ALDH1A1 3322/4885MTNR1A 1932/4885 |
| US-20060040961-A1 | Furanopyrimidines | TYMS, IDO1, NFATC1 | LTA4H 592/4885ALDH1A1 159/4885MTNR1A 488/4885 |
| US-20210300872-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | HSP90B1, HSP90AB2P, HSPE1 | LTA4H 3870/4885ALDH1A1 3322/4885MTNR1A 1932/4885 |
| US-20250257027-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | HSP90B1, HSP90AB2P, HSPE1 | LTA4H 3878/4885ALDH1A1 3289/4885MTNR1A 1834/4885 |
| US-11028041-B2 | Second generation GRP94-selective inhibitors | HSP90B1, HSP90AB2P, HSPE1 | LTA4H 3878/4885ALDH1A1 3289/4885MTNR1A 1834/4885 |
| US-20200190017-A1 | SECOND GENERATION GRP94-SELECTIVE INHIBITORS | HSP90B1, HSP90AB2P, HSPE1 | LTA4H 3878/4885ALDH1A1 3289/4885MTNR1A 1834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.