Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20089299 | 1.00 | PLAU (0.30) | PLAUKDM4EPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL10872964 | 0.74 | POLB (0.33) | KDM4EPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL8435296 | 0.74 | DPP4 (0.39) | KDM4ESMN1; SMN2 | |
| SCHEMBL20089301 | 0.72 | DGAT1 (0.30) | — | |
| SCHEMBL23235003 | 0.72 | POLB (0.40) | PLAUPOLBSMN1; SMN2 | |
| SCHEMBL27740193 | 0.63 | ALDH1A1 (0.43) | — | |
| SCHEMBL30562670 | 0.63 | ALDH1A1 (0.44) | PLAUKDM4ESMN1; SMN2 | |
| SCHEMBL19028056 | 0.63 | ALDH1A1 (0.44) | PLAUKDM4ESMN1; SMN2 | |
| SCHEMBL20089311 | 0.63 | BACE1 (0.32) | — | |
| SCHEMBL20089293 | 0.62 | PLAU (0.30) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436662-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | Novartis AG (CH) | 2024-10-02 | — | — | EP | disclosed |
| CN-118382623-A | Naphthyridinone derivatives for use in the treatment of diseases or disorders | 诺华股份有限公司 | 2024-07-23 | — | — | CN | disclosed |
| WO-2023094965-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-06-01 | — | — | WO | disclosed |
| CN-109843887-B | Nalidinone derivatives and their use in the treatment of cardiac arrhythmias | 诺华股份有限公司 | 2022-05-10 | — | — | CN | disclosed |