Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29623571 | 1.00 | PLAU (0.30) | PLAUKDM4EPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL10872964 | 0.74 | POLB (0.33) | KDM4EPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL8435296 | 0.74 | DPP4 (0.39) | KDM4ESMN1; SMN2 | |
| SCHEMBL20089301 | 0.72 | DGAT1 (0.30) | — | |
| SCHEMBL23235003 | 0.72 | POLB (0.40) | PLAUPOLBSMN1; SMN2 | |
| SCHEMBL27740193 | 0.63 | ALDH1A1 (0.43) | — | |
| SCHEMBL30562670 | 0.63 | ALDH1A1 (0.44) | PLAUKDM4ESMN1; SMN2 | |
| SCHEMBL19028056 | 0.63 | ALDH1A1 (0.44) | PLAUKDM4ESMN1; SMN2 | |
| SCHEMBL20089311 | 0.63 | BACE1 (0.32) | — | |
| SCHEMBL20089293 | 0.62 | PLAU (0.30) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4656240-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | Novartis AG (CH) | 2025-12-03 | — | — | EP | disclosed |
| EP-4436662-B1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2025-09-17 | — | — | EP | disclosed |
| US-20250214989-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2025-07-03 | — | — | US | disclosed |
| EP-4436662-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | Novartis AG (CH) | 2024-10-02 | — | — | EP | disclosed |
| US-12084442-B2 | Naphthyridinone derivatives for the treatment of a disease or disorder | NOVARTIS AG (CH) | 2024-09-10 | — | — | US | disclosed |
| US-20230203032-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-06-29 | — | — | US | disclosed |
| US-20230203032-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-06-29 | — | — | US | disclosed |
| US-20230203032-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-06-29 | — | — | US | disclosed |
| WO-2023094965-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-06-01 | — | — | WO | disclosed |
| EP-4141006-A1 | NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | Novartis AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| US-20190263803-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2019-08-29 | — | — | US | disclosed |
| US-20190263803-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2019-08-29 | — | — | US | disclosed |
| EP-3529251-A1 | NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | Novartis AG (CH) | 2019-08-28 | — | — | EP | disclosed |
| US-10266531-B2 | Naphthyridinone derivatives and their use in the treatment of arrhythmia | NOVARTIS AG (CH) | 2019-04-23 | — | — | US | disclosed |
| US-10266531-B2 | Naphthyridinone derivatives and their use in the treatment of arrhythmia | NOVARTIS AG (CH) | 2019-04-23 | — | — | US | disclosed |
| WO-2018073788-A1 | NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | NOVARTIS AG (CH) | 2018-04-26 | — | — | WO | disclosed |
| US-20180111932-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | NOVARTIS AG (CH) | 2018-04-26 | — | — | US | disclosed |
| WO-2018073788-A1 | NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | NOVARTIS AG (CH) | 2018-04-26 | — | — | WO | disclosed |
| US-20180111932-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | NOVARTIS AG (CH) | 2018-04-26 | — | — | US | disclosed |
| US-20180111932-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | NOVARTIS AG (CH) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266531-B2 | Naphthyridinone derivatives and their use in the treatment of arrhythmia | SCN1B, NPR3, SCN3A | PLAU 4192/4885KDM4E 1891/4885POLB 2276/4885 |
| US-20180111932-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | SCN1B, SCN3A, SCN5A | PLAU 4389/4885KDM4E 1689/4885POLB 2619/4885 |
| US-20190263803-A1 | NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA | SCN1B, SCN3A, SCN5A | PLAU 4389/4885KDM4E 1689/4885POLB 2619/4885 |
| US-12084442-B2 | Naphthyridinone derivatives for the treatment of a disease or disorder | PKD1, PKD2, ASAH2 | PLAU 3500/4885KDM4E 3422/4885POLB 200/4885 |
| US-20250214989-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | PKD1, PKD2, ASAH2 | PLAU 3500/4885KDM4E 3422/4885POLB 200/4885 |
| US-20230203032-A1 | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | PKD1, PKD2, ASAH2 | PLAU 3500/4885KDM4E 3422/4885POLB 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.