Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propyphenazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 2/20 | 0.62 |
| ▸ | ADORA2B known ✓ | P29275 | 2/20 | 0.56 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.56 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.56 |
| ▸ | MC3R | P41968 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.56 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.56 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propyphenazone SCHEMBL29363983 | 0.87 | ADORA3 (0.47) | ADORA3LMNAPOLBADORA2BPIK3CD | |
| Ampyrone SCHEMBL27612823 | 0.85 | BCHE (0.61) | ADORA3POLBADORA2BPIK3CDCNR1 | |
| Propyphenazone SCHEMBL23393 | 0.79 | LMNA (1.00) | ADORA3LMNAPOLBPTGS2SMN1; SMN2 | |
| Propyphenazone SCHEMBL7929540 | 0.78 | LMNA (0.97) | ADORA3LMNAPOLBPTGS2SMN1; SMN2 | |
| Caffeine SCHEMBL29549294 | 0.74 | ADORA2B (1.00) | ADORA3LMNAPOLBADORA2BPIK3CD | |
| Caffeine SCHEMBL901194 | 0.74 | ADORA2B (1.00) | ADORA3LMNAPOLBADORA2BPIK3CD | |
| Caffeine SCHEMBL29590919 | 0.74 | ADORA2B (1.00) | ADORA3LMNAPOLBADORA2BPIK3CD | |
| Caffeine SCHEMBL5671 | 0.74 | ADORA2B (1.00) | ADORA3LMNAPOLBADORA2BPIK3CD | |
| Caffeine SCHEMBL8569482 | 0.74 | ADORA2B (1.00) | ADORA3LMNAPOLBADORA2BPIK3CD | |
| Caffeine SCHEMBL29549224 | 0.74 | ADORA2B (1.00) | ADORA3LMNAPOLBADORA2BPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562387-B1 | EXPANDABLE MEMBER FOR AN ELECTROPHYSIOLOGY CATHETER | ABBOTT CARDIOVASCULAR SYSTEMS INC (US) | 2024-06-12 | — | — | EP | claimed |
| US-11344259-B2 | Expandable member for an electrophysiology catheter | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2022-05-31 | — | — | US | claimed |
| US-12419580-B2 | Expandable member for an electrophysiology catheter | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2025-09-23 | — | — | US | disclosed |
| EP-4400035-A2 | EXPANDABLE MEMBER FOR AN ELECTROPHYSIOLOGY CATHETER | Abbott Cardiovascular Systems Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| EP-3562387-B1 | EXPANDABLE MEMBER FOR AN ELECTROPHYSIOLOGY CATHETER | ABBOTT CARDIOVASCULAR SYSTEMS INC (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-116664734-B | Method for displaying ring chart, electronic device and readable storage medium | 荣耀终端有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-116664734-A | Method for displaying ring chart, electronic device and readable storage medium | 荣耀终端有限公司 | 2023-08-29 | — | — | CN | disclosed |
| US-20220273241-A1 | EXPANDABLE MEMBER FOR AN ELECTROPHYSIOLOGY CATHETER | ABBOTT CARDIOVASCULAR SYSTEMS INC. | 2022-09-01 | — | — | US | disclosed |
| US-11344259-B2 | Expandable member for an electrophysiology catheter | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2022-05-31 | — | — | US | disclosed |