Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1643330 | 0.98 | TSHR (0.62) | TSHRALDH1A1LMNACYP1A2USP2 | |
| SCHEMBL466314 | 0.98 | TSHR (0.62) | TSHRALDH1A1LMNACYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL3648260 | 0.96 | TSHR (0.60) | TSHRALDH1A1LMNACYP1A2USP2 | |
| SCHEMBL29774533 | 0.96 | TSHR (0.53) | TSHRALDH1A1LMNACYP1A2USP2 | |
| SCHEMBL16314979 | 0.94 | TSHR (0.50) | TSHRALDH1A1LMNACYP1A2USP2 | |
| SCHEMBL17916993 | 0.85 | TSHR (0.43) | TSHRALDH1A1LMNACYP1A2USP2 | |
| SCHEMBL4691009 | 0.85 | TSHR (0.43) | TSHRALDH1A1LMNACYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL25210568 | 0.83 | LMNA (0.42) | TSHRALDH1A1LMNACYP1A2USP2 | |
| SCHEMBL14393923 | 0.82 | TSHR (0.38) | TSHRALDH1A1LMNACYP1A2USP2 | |
| SCHEMBL14534858 | 0.82 | USP2 (0.62) | TSHRALDH1A1LMNACYP1A2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257057-A1 | BICYCLIC CX3CR1 RECEPTOR AGONISTS | GOLGI NEUROSCIENCES S.R.I. (IT) | 2025-08-14 | — | — | US | disclosed |
| US-12258337-B2 | Bicyclic CX3CR1 receptor agonists | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2025-03-25 | — | — | US | disclosed |
| US-20240150332-A1 | BICYCLIC CX3CR1 RECEPTOR AGONISTS | GOLGI NEUROSCIENCES S.R.L. (IT) | 2024-05-09 | — | — | US | disclosed |
| US-11958839-B2 | Bicyclic CX3CR1 receptor agonists | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-04-16 | — | — | US | disclosed |
| US-20220259191-A1 | BICYCLIC CX3CR1 RECEPTOR AGONISTS | GOLGI NEUROSCIENCES S.R.L. (IT) | 2022-08-18 | — | — | US | disclosed |
| EP-4003972-A1 | BICYCLIC CX3CR1 RECEPTOR AGONISTS | Board of Regents, The University of Texas System (US) | 2022-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12258337-B2 | Bicyclic CX3CR1 receptor agonists | CX3CR1, CCR2, CCR5 | TSHR 548/4885ALDH1A1 2783/4885LMNA 3542/4885 |
| US-20220259191-A1 | BICYCLIC CX3CR1 RECEPTOR AGONISTS | CX3CR1, CCR2, CCR5 | TSHR 548/4885ALDH1A1 2783/4885LMNA 3542/4885 |
| US-20250257057-A1 | BICYCLIC CX3CR1 RECEPTOR AGONISTS | CX3CR1, CCR2, CCR5 | TSHR 548/4885ALDH1A1 2783/4885LMNA 3542/4885 |
| US-11958839-B2 | Bicyclic CX3CR1 receptor agonists | CX3CR1, CCR2, CCR5 | TSHR 548/4885ALDH1A1 2783/4885LMNA 3542/4885 |
| US-20240150332-A1 | BICYCLIC CX3CR1 RECEPTOR AGONISTS | CX3CR1, CCR2, CCR5 | TSHR 548/4885ALDH1A1 2783/4885LMNA 3542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.