Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24275809 | 0.87 | SYK (0.33) | SYKMAPK1NFKB1NFKB2RELA | |
| SCHEMBL24275808 | 0.75 | SYK (0.38) | SYKMAPK1NFKB1NFKB2RELA | |
| SCHEMBL4735920 | 0.73 | CYP3A4 (0.41) | SYKKMT2AALDH1A1HPGDCYP1A2 | |
| SCHEMBL15052607 | 0.73 | ALDH1A1 (0.38) | SYKNFKB1NFKB2RELAKMT2A | |
| SCHEMBL12381778 | 0.72 | KMT2A (0.46) | MAPK1KMT2AALDH1A1HPGDCYP1A2 | |
| SCHEMBL21608043 | 0.70 | IDO1 (0.39) | SYKNFKB1NFKB2RELAKMT2A | |
| SCHEMBL24275860 | 0.70 | GAA (0.40) | SYKNFKB1NFKB2RELAKMT2A | |
| SCHEMBL2029380 | 0.69 | HTT (0.41) | MAPK1KMT2AALDH1A1HPGDCYP1A2 | |
| SCHEMBL16760289 | 0.68 | CRHBP (0.40) | SYKMAPK1NFKB1NFKB2RELA | |
| SCHEMBL3382885 | 0.68 | RAB9A (0.51) | MAPK1KMT2AABCB1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022053010-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-03-17 | — | — | WO | disclosed |