Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377596 | 0.89 | ALDH1A1 (0.46) | KDM4ELMNAALDH1A1HPGDGAA | |
| SCHEMBL29814284 | 0.86 | MET (0.47) | KDM4EKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL19377733 | 0.81 | ALDH1A1 (0.50) | KDM4EADORA2AADORA1KMT2AALDH1A1 | |
| SCHEMBL14969120 | 0.77 | MET (0.48) | KDM4ELMNAKMT2AALDH1A1POLB | |
| SCHEMBL19429548 | 0.74 | KDM4C (0.39) | KDM4ELMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL21786094 | 0.71 | AXL (0.44) | ALDH1A1TYRO3HTTMETAXL | |
| SCHEMBL22931498 | 0.70 | MEN1 (0.38) | LMNAKMT2AALDH1A1MEN1GAA | |
| SCHEMBL29625543 | 0.70 | KMT2A (0.48) | KDM4EKMT2ATYRO3GSK3AGSK3B | |
| SCHEMBL248654 | 0.70 | GSK3A (0.47) | KDM4ELMNAPKMKMT2AALDH1A1 | |
| SCHEMBL22349870 | 0.70 | MEN1 (0.42) | LMNAKMT2AALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |