Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21785556 | 0.86 | ALDH1A1 (0.39) | GSK3AGSK3BALDH1A1TSHRPOLB | |
| SCHEMBL19377596 | 0.77 | ALDH1A1 (0.46) | GSK3AGSK3BPGRALDH1A1TSHR | |
| SCHEMBL29626153 | 0.74 | KDM4E (0.48) | GSK3AGSK3BPGRALDH1A1KMT2A | |
| SCHEMBL22349870 | 0.72 | MEN1 (0.42) | GSK3AGSK3BALDH1A1KMT2AGAA | |
| SCHEMBL19377733 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KMT2AGAAMAPTHTT | |
| SCHEMBL22931498 | 0.70 | MEN1 (0.38) | GSK3AGSK3BALDH1A1KMT2AGAA | |
| SCHEMBL19429625 | 0.69 | KMT2A (0.40) | GSK3AGSK3BPGRALDH1A1KMT2A | |
| SCHEMBL4477389 | 0.67 | HTR4 (0.41) | ALDH1A1KMT2APOLBSMN1; SMN2CYP1A2 | |
| SCHEMBL13114753 | 0.66 | ROCK2 (0.40) | GSK3AGSK3BTSHRKMT2AMAPT | |
| SCHEMBL21785519 | 0.66 | MET (0.40) | GSK3AGSK3BALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |