Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.45 |
| ▸ | BCHE | P06276 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2243227 | 0.90 | NPC1 (0.48) | ACHEBCHENPC1RAB9AHTT | |
| SCHEMBL9865544 | 0.90 | TP53 (0.45) | ACHEBCHENPC1RAB9AHTT | |
| SCHEMBL12354613 | 0.79 | NPC1 (0.44) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL9701184 | 0.76 | NPC1 (0.51) | ACHENPC1RAB9AHTTMEN1 | |
| SCHEMBL12354600 | 0.74 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2ATAS2R14 | |
| SCHEMBL14174100 | 0.72 | NPC1 (0.63) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL3456951 | 0.68 | ACHE (0.65) | ACHEBCHENPC1RAB9AHTT | |
| SCHEMBL14174295 | 0.67 | TSPO (0.59) | NPC1RAB9AHTTSMN1; SMN2LMNA | |
| SCHEMBL28858711 | 0.67 | LMNA (0.39) | NPC1RAB9ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL257535 | 0.67 | NPC1 (0.53) | NPC1RAB9AHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003339-A2 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-06-01 | — | — | EP | disclosed |